University of Texas Southwestern Medical Center
studied medicine at the University of Chicago. Early in his career he isolated
mouse TNF, and discovered its inflammatory properties. Later he developed TNF
inhibitor proteins that found widespread use in clinical medicine. Using
genetics, and taking the TNF response as a biological endpoint, he then
identified Toll-like receptor 4 as the mammalian sensor of bacterial
groundbreaking studies of innate immune sensing and response earned Beutler the
2011 Nobel Prize in Physiology or Medicine (shared with J. Hoffmann and R.
Steinman). Beutler directs the Center for the Genetics of Host Defense, UT
Southwestern Medical Center, Dallas, TX.